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Regulation of the HIF switch in human endothelial and cancer cells

21 Jan 2024

Abstract excerpt

Hypoxia-inducible factors (HIFs) are transcription factors that reprogram the transcriptome for cells to survive hypoxic insults and oxidative stress. They are important during embryonic development and reprogram the cells to utilize glycolysis when the oxygen levels are extremely low. This metabolic change facilitates normal cell survival as well as cancer cell survival. The key feature in survival is the...

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PMID: 38262137
DOI: 10.1016/j.ejcb.2024.151386

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