Article

Characterisation of HIF-dependent alternative isoforms in pancreatic cancer

2019-10-31

Abstract excerpt

Intra-tumor hypoxia is a common feature in many solid cancers. Although transcriptional targets of hypoxia-inducible factors (HIFs) have been well characterized, alternative splicing or processing of pre-mRNA transcripts which occurs during hypoxia and subsequent HIF stabilization is much less understood. Here, we identify HIF-dependent alternative splicing events after whole transcriptome sequencing in pancreatic...

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Literature Corpus work: 6a152eec-d3dd-5e13-9243-7c93c5f7908d
DOI: 10.1101/826156

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