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Article

No association between butyrylcholinesterase K-variant and Alzheimer disease in Chinese.

American journal of medical genetics - 3 Apr 2000

Lee D W, Liu H C, Liu T Y, Chi C W, Hong C J

Abstract excerpt

Increased butyrylcholinesterase (BChE) activity has been reported to be associated with the formation of amyloid plaques and neurofibrillary tangles and may consequently be involved in the pathogenesis of Alzheimer disease (AD). Because the catalytic activity of BChE-K variant is reduced by one-third compared with non-variant, we speculated that BChE-K variant has a protective effect on AD. However, Lehmann et...

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PMID: 10893490

Genes

BCHE
APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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No association between butyrylcholinesterase K-variant and Alzheimer disease in Chinese.PMID 10893490Read ↗

No association between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset Alzheimer's disease.Semantic proximity Read ↗

Butyrylcholinesterase K variant and Alzheimer's disease risk: a meta-analysis.Semantic proximity Read ↗

The butyrylcholinesterase gene is neither independently nor synergistically associated with late-onset AD in clinic- and community-based populations.Semantic proximity Read ↗

Butyrylcholinesterase K variant and apolipoprotein E4 genes do not act in synergy in Finnish late-onset Alzheimer's disease patients.Semantic proximity Read ↗

Analysis of association between butyrylcholinesterase K variant and apolipoprotein E genotypes in Alzheimer's disease.Semantic proximity Read ↗

Failure to confirm a synergistic effect between the K-variant of the butyrylcholinesterase gene and the epsilon4 allele of the apolipoprotein gene in Japanese patients with Alzheimer's disease.Semantic proximity Read ↗

The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease.Semantic proximity Read ↗

Butyrylcholinesterase K variant is genetically associated with late onset Alzheimer's disease in Northern Ireland.Semantic proximity Read ↗

Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer's disease.Semantic proximity Read ↗

No association between the K variant of the butyrylcholinesterase gene and pathologically confirmed Alzheimer's disease.Semantic proximity Read ↗

The butyrylcholinesterase K variant is a protective factor for sporadic Alzheimer's disease in women.Semantic proximity Read ↗

Neither the butyrylcholinesterase K variant nor transferrin C2 variant confers a risk for Alzheimer's disease in Koreans.Semantic proximity Read ↗

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