Article
No association between the K variant of the butyrylcholinesterase gene and pathologically confirmed Alzheimer's disease.
Human molecular genetics - 1 May 1998
Singleton A B, Smith G, Gibson A M, Woodward R, Perry R H, Ince P G, Edwardson J A, Morris C M
Abstract excerpt
The polymorphic K variant of the butyrylcholinesterase ( BCHE-K ) gene recently has been demonstrated to have an elevated frequency in Alzheimer's disease (AD) patients carrying the epsilon4 allele of the apolipoprotein (APO E) gene when compared with a control population. We therefore genotyped...
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Brain
- Butyrylcholinesterase
- DNA
- Gene Frequency
- Genetic Linkage
- Genotype
- Humans
- Middle Aged
- Neurofibrillary Tangles
- Plaque, Amyloid
- Point Mutation