Article
Association between the dopamine D3 receptor gene locus (DRD3) and unipolar affective disorder.
Psychiatric genetics - 1 Dec 1999
Dikeos D G, Papadimitriou G N, Avramopoulos D, Karadima G, Daskalopoulou E G, Souery D, Mendlewicz J, Vassilopoulos D, Stefanis C N
Abstract excerpt
Dopamine neurotransmission has been implicated in the pathophysiology of schizophrenia and, more recently, affective disorders. Among the dopamine receptors, D3 can be considered as particularly related to affective disorders due to its neuroanatomical localization in the limbic region of the brain and its relation to the serotoninergic activity of the CNS. The possible involvement of dopamine receptor D3 in...
Topics
- Adult
- Aged
- Chromosome Mapping
- Chromosomes, Human, Pair 3
- Deoxyribonucleases, Type II Site-Specific
- Depressive Disorder
- Ethnicity
- Europe
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Polymorphism, Restriction Fragment Length