Article
Preliminary evidence for an association between a dopamine D3 receptor gene variant and obsessive-compulsive personality disorder in patients with major depression.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2006
Light Katrina J, Joyce Peter R, Luty Suzanne E, Mulder Roger T, Frampton Christropher M A, Joyce Laura R M, Miller Allison L, Kennedy Martin A
Abstract excerpt
We have previously reported that the Ser9Gly dopamine D3 receptor (DRD3) polymorphism was associated with increased rates of obsessive-compulsive personality disorder (OCPD) symptomology. We tested the replicability of this association within a further two independent groups of individuals with a history of depression, from a clinical sample (n = 149) and a family study (n = 213). The data from the replication...
Topics
- Adult
- Compulsive Personality Disorder
- Depressive Disorder, Major
- Family Health
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Logistic Models
- Male
- Middle Aged