Article
Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European Multicenter Association Study of affective disorders.
American journal of medical genetics - 8 Mar 2002
Massat Isabelle, Souery Daniel, Del-Favero Jurgen, Van Gestel Sofie, Serretti Alessandro, Macciardi Fabio, Smeraldi Enrico, Kaneva Radka, Adolfsson Rolf, Nylander Peter O, Blackwood Douglas, Muir Walter, Papadimitriou George N, Dikeos Dimitris, Oruc Lilijana, Segman Ronnen H, Ivezic Sladjana, Aschauer Harold, Ackenheil Manfred, Fuchshuber S, Dam Henrik, Jakovljevic Miro, Peltonen Leena, Hilger Christiane, Hentges François, Staner Luc, Milanova Vihra, Jazin Elena, Lerer Bernard, Van Broeckhoven Christine, Mendlewicz Julien
Abstract excerpt
Convincing evidence for a genetic component in the etiology of affective disorders (AD), including bipolar affective disorder (BPAD) and unipolar affective disorder (UPAD), is supported by traditional and molecular genetic studies. Most arguments lead to the complex inheritance hypothesis, suggesting that the mode of inheritance is probably not Mendelian but most likely oligogenic (or polygenic) and that the...
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