Article
No evidence of association between dopamine D4 receptor variants and bipolar affective disorder.
American journal of medical genetics - 15 Sept 1994
Lim L C, Nöthen M M, Körner J, Rietschel M, Castle D, Hunt N, Propping P, Murray R, Gill M
Abstract excerpt
Disturbance in the dopamine neurotransmitter system has been implicated in the pathogenesis of affective disorder. In this study, we examine the possibility that functional variants of the recently cloned dopamine D4 receptor gene contribute to the genetic component of manic depression. The polymorphism, a 48 bp tandem repeat coding for part of the third cytoplasmic loop, was detected using a PCR based method. In...
Topics
- Alleles
- Bipolar Disorder
- Female
- Humans
- Male
- Polymerase Chain Reaction
- Receptors, Dopamine
- Receptors, Dopamine D2
- Receptors, Dopamine D4
- Repetitive Sequences, Nucleic Acid