Article
The difference between benign and malignant tumours explained with the 4-mutation paradigm for carcinogenesis.
Anticancer research - 1 Jan 2000
Koten J W, Neijt J P, Zonnenberg B A, Den Otter W
Abstract excerpt
In recent years a 4-mutation paradigm for carcinogenesis was developed for mutations in tumour suppressor genes. The major tenet of this paradigm is that transformation of a normal cell into a malignant cell is the result of an accumulation of a set of 4 specific cancer mutations. In this paper we show that this paradigm can explain the characteristic differences between benign and malignant tumours. We surmise...
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