A new model for oncogenesis. From tumour immunology to a mathematical approach of oncogenesis.

Abstract excerpt

Around 1970 it was assumed that tumour cells are due to a single specific oncogenic mutation. This implied that daily many thousands of tumour cells would arise de novo and that most of these tumour cells were killed by immune surveillance or natural resistance mechanisms. Recent findings on immune surveillance and natural resistance implicate that tumour cells do not arise frequently, however. Given the fact...

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