Article
Influence of factor VIII/von Willebrand complex on the activated protein C-resistance phenotype and on the risk for venous thromboembolism in heterozygous carriers of the factor V Leiden mutation.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Oct 1999
De Mitrio V, Marino R, Scaraggi F A, Di Bari L, Giannoccaro F, Petronelli M, Ranieri P, Tannoia N, Schiraldi O
Abstract excerpt
High factor VIII plasma levels have been shown to represent a common increased risk for venous thromboembolism (VTE) and may cause an activated protein C (APC) resistance in the absence of the factor V Leiden mutation, but there are no studies specifically aimed to establish if high factor VIII and von Willebrand factor (vWF) concentrations may influence the APC sensitivity ratio (APC-SR) and increase the risk...
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