Article
Cre-mediated cerebellum- and hippocampus-restricted gene mutation in mouse brain.
Biochemical and biophysical research communications - 5 Mar 2000
Guo H, Mao C, Jin X L, Wang H, Tu Y T, Avasthi P P, Li Y
Abstract excerpt
Using the phage P1-derived Cre/loxP recombination system, we have created a line of cre-transgenic mice in which the Cre-mediated gene deletion is restricted to granule cells of cerebellum and dentate gyrus of hippocampus. Low levels of deletion were also present in pyramidal cells of hippocampal CA1 and CA3 fields. The Cre/loxP recombination occurred prenatally. The recombination efficiencies in the granular...
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