Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice.

doi:10.1016/0896-6273(92)90247-b

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Article

Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice.

Neuron - 1 Nov 1992

Feddersen R M, Ehlenfeldt R, Yunis W S, Clark H B, Orr H T

Abstract excerpt

SV40 T antigen (Tag) expression directed to cerebellar Purkinje cells resulted in the generation of three transgenic mouse lines that displayed ataxia, a neurological phenotype characteristic of cerebellar dysfunction. Onset of symptoms and cerebellar pathology, characterized by specific Purkinje cell degeneration, appeared to be directly dependent upon transgene copy number. The SV5 line (containing > 30...

Topics

Animals
Antigens, Polyomavirus Transforming
Ataxia
Base Sequence
Blotting, Southern
Cell Death
Cell Division
Cell Movement
Cerebellar Cortex
Gene Expression
Genes, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunohistochemistry

Mice

Mice, Transgenic

Molecular Sequence Data

Nerve Degeneration

Phenotype

Purkinje Cells

Source

Open in PubMed

Identifiers

PMID: 1419002
DOI: 10.1016/0896-6273(92)90247-b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1419002-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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