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Article

High resolution x-ray analysis of two mutants of a curaremimetic snake toxin.

European journal of biochemistry - 1 Mar 2000

Gaucher J F, Ménez R, Arnoux B, Pusset J, Ducruix A

Abstract excerpt

A previous mutational analysis of erabutoxin a (Ea), a curaremimetic toxin from sea snake venom, showed that the substitutions S8G and S8T caused, respectively, 176-fold and 780-fold affinity decreases for the nicotinic acetylcholine receptor (AchR). In view of the fact that the side-chain of Ser8 is buried in the wild-type toxin, we wondered whether these affinity changes reflect a direct binding contribution of...

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PMID: 10691969
DOI: 10.1046/j.1432-1327.2000.01099.x

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