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Article

Bacterial expression, NMR, and electrophysiology analysis of chimeric short/long-chain alpha-neurotoxins acting on neuronal nicotinic receptors.

The Journal of biological chemistry - 24 Aug 2007

Lyukmanova Ekaterina N, Shenkarev Zakhar O, Schulga Alexey A, Ermolyuk Yaroslav S, Mordvintsev Dmitry Yu, Utkin Yurii N, Shoulepko Mikhail A, Hogg Ron C, Bertrand Daniel, Dolgikh Dmitry A, Tsetlin Victor I, Kirpichnikov Mikhail P

Abstract excerpt

Different snake venom neurotoxins block distinct subtypes of nicotinic acetylcholine receptors (nAChR). Short-chain alpha-neurotoxins preferentially inhibit muscle-type nAChRs, whereas long-chain alpha-neurotoxins block both muscle-type and alpha7 homooligomeric neuronal nAChRs. An additional disulfide in the central loop of alpha- and kappa-neurotoxins is essential for their action on the alpha7 and alpha3beta2...

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PMID: 17576769
DOI: 10.1074/jbc.M611263200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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