Article
Paraoxonase polymorphism (Gln192Arg) as a determinant of the response of human coronary arteries to serotonin.
Circulation - 22 Feb 2000
Bauters C, Amant C, Boullier A, Cabrol P, McFadden E, Duriez P, Bertrand M E, Amouyel P, Boulier A
Abstract excerpt
Background-Oxidation of LDL plays a role in endothelial dysfunction. Paraoxonase, an enzyme present on HDL, protects LDL against oxidation. Paraoxonase activity is genetically determined in part, and 3 genotypes have been described with variable enzymatic activity. We hypothesized that the paraoxonase polymorphism might influence endothelial function. Methods and Results-Twenty-seven patients with clinical...
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