Article
Impact of paraoxonase polymorphism (Q192R) on endothelial function in intact coronary circulation.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Jun 2006
Yamane Tetsunobu, Matsumoto Tetsuya, Nakae Ichiro, Takashima Hiroyuki, Tarutani Yasuhiro, Tamaki Shinji, Horie Minoru
Abstract excerpt
Paraoxonase-1 (PON1) can protect endothelial function by preventing the oxidation of low-density lipoprotein (LDL) cholesterol and retarding the development of atherosclerosis. We examined whether PON1 polymorphism influences endothelium-dependent coronary vasomotor responses. Sixty-seven patients underwent diagnostic cardiac catheterization, but showed no significant coronary artery stenosis. In all patients,...
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