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Article

A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease.

The Journal of clinical investigation - 1 Dec 1995

Serrato M, Marian A J

Abstract excerpt

Coronary artery disease (CAD) is a complex trait caused by a number of genetic and environmental factors. Recently, paraoxonase/arylesterase (PONA) enzyme has been implicated in the pathogenesis of atherosclerosis. There is a 10-40-fold variability in the activity of this enzyme among individuals. This variability is due to the presence of an A/G polymorphism in the coding region of the gene (HUMPONA). The A and...

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Identifiers

PMID: 8675673
DOI: 10.1172/JCI118373
PMCID: PMC186013

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease.PMID 8675673Read ↗

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