Article
Glutathione S-transferase A1, M1, P1 and T1 null or low-activity genotypes are associated with enhanced oxidative damage among haemodialysis patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Jan 2013
Suvakov Sonja, Damjanovic Tatjana, Stefanovic Aleksandra, Pekmezovic Tatjana, Savic-Radojevic Ana, Pljesa-Ercegovac Marija, Matic Marija, Djukic Tatjana, Coric Vesna, Jakovljevic Jovana, Ivanisevic Jasmina, Pljesa Steva, Jelic-Ivanovic Zorana, Mimic-Oka Jasmina, Dimkovic Nada, Simic Tatjana
Abstract excerpt
BACKGROUND: Increased oxidative stress is a hallmark of end-stage renal disease (ESRD). Glutathione S-transferases (GST) are involved in the detoxification of xenobiotics and protection of oxidative damage. We hypothesized that genetic polymorphism in antioxidant enzymes GSTA1, GSTM1, GSTP1 and GSTT1 is more frequent in ESRD and modulates the degree of oxidative stress in these patients. METHODS: GSTA1, GSTM1,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.