Article
Granulocyte macrophage colony stimulating factor exerts dominant effects over macrophage colony stimulating factor during macrophage differentiation in vitro to induce an inflammatory phenotype.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 1 Feb 2024
Petrina Maria, Alothaimeen Torki, Bouzeineddine Nasry Zane, Trus Evan, Banete Andra, Gee Katrina, Basta Sameh
Abstract excerpt
BACKGROUND: Macrophages (Mφ) can exist along a spectrum of phenotypes that include pro-inflammatory (M1) or anti-inflammatory (M2) immune cells. Mφ colony stimulating factor (M-CSF) and granulocyte Mφ colony stimulating factor (GM-CSF) are cytokines important in hematopoiesis, polarization and activation of Mφ. METHODS AND RESULTS: To gain a greater understanding of the relationship between GM-CSF and M-CSF, we...
Topics
- Anti-Inflammatory Agents
- Cell Differentiation
- Cells, Cultured
- Cytokines
- Granulocyte-Macrophage Colony-Stimulating Factor
- Hematopoiesis
- Macrophage Colony-Stimulating Factor
- Macrophages
- Phenotype