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Article

Studies on the role of the hydrophobic domain of Ost4p in interactions with other subunits of yeast oligosaccharyl transferase.

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2000

Kim H, Park H, Montalvo L, Lennarz W J

Abstract excerpt

In the yeast, Saccharomyces cerevisiae, oligosaccharyl transferase (OT), which catalyzes the transfer of dolichol-linked oligosaccharide chains to nascent polypeptides in the endoplasmic reticulum, consists of nine nonidentical membrane protein subunits. Genetic and biochemical evidence indicated these nine proteins exist in three subcomplexes. Three of the OT subunits (Ost4p, Ost3p, and Stt3p) have been proposed...

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Identifiers

PMID: 10677492
DOI: 10.1073/pnas.040556797
PMCID: PMC26466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Studies on the role of the hydrophobic domain of Ost4p in interactions with other subunits of yeast oligosaccharyl transferase.PMID 10677492Read ↗

Determination of the membrane topology of Ost4p and its subunit interactions in the oligosaccharyltransferase complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

The oligosaccharyltransferase complex from Saccharomyces cerevisiae. Isolation of the OST6 gene, its synthetic interaction with OST3, and analysis of the native complex.Semantic proximity Read ↗

Studies on the N-glycosylation of the subunits of oligosaccharyl transferase in Saccharomyces cerevisiae.Semantic proximity Read ↗

A specific segment of the transmembrane domain of Wbp1p is essential for its incorporation into the oligosaccharyl transferase complex.Semantic proximity Read ↗

A specific screen for oligosaccharyltransferase mutations identifies the 9 kDa OST5 protein required for optimal activity in vivo and in vitro.Semantic proximity Read ↗

NMR and MD simulations reveal the impact of the V23D mutation on the function of yeast oligosaccharyltransferase subunit Ost4.Semantic proximity Read ↗

The OST4 gene of Saccharomyces cerevisiae encodes an unusually small protein required for normal levels of oligosaccharyltransferase activity.Semantic proximity Read ↗

The STT3 protein is a component of the yeast oligosaccharyltransferase complex.Semantic proximity Read ↗

Studies on the function of oligosaccharyl transferase subunits. Stt3p is directly involved in the glycosylation process.Semantic proximity Read ↗

STT3, a highly conserved protein required for yeast oligosaccharyl transferase activity in vivo.Semantic proximity Read ↗

Polypeptide binding specificities of Saccharomyces cerevisiae oligosaccharyltransferase accessory proteins Ost3p and Ost6p.Semantic proximity Read ↗

Biochemistry, molecular biology, and genetics of the oligosaccharyltransferase.Semantic proximity Read ↗

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