Article
DRD4 exon III VNTR polymorphism-susceptibility factor for heroin dependence? Results of a case-control and a family-based association approach.
Molecular psychiatry - 1 Jan 2000
Franke P, Nöthen M M, Wang T, Knapp M, Lichtermann D, Neidt H, Sander T, Propping P, Maier W
Abstract excerpt
Dopaminergic abnormalities are implicated in the pathogenesis of substance abuse.1 Recently, two reports have been published suggesting an association between opioid dependence and presence of long alleles of the dopamine D4 receptor (DRD4) gene exon III VNTR.2, 3 We have attempted to replicate this finding using a two-tiered strategy employing independent case-control and family-based association samples. Our...
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