Article
Energetics of a strongly pH dependent RNA tertiary structure in a frameshifting pseudoknot.
Journal of molecular biology - 18 Feb 2000
Nixon P L, Giedroc D P
Abstract excerpt
Retroviruses employ -1 translational frameshifting to regulate the relative concentrations of structural and non-structural proteins critical to the viral life cycle. The 1.6 A crystal structure of the -1 frameshifting pseudoknot from beet western yellows virus reveals, in addition to Watson-Crick base-pairing, many loop-stem RNA tertiary structural interactions and a bound Na(+). Investigation of the...
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