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Article

Protein folding and deficiencies caused by dominant-negative mutants of hormones.

Vitamins and hormones - 1 Jan 2000

Dannies P S

Abstract excerpt

Protein folding and transport in the secretory pathway of cells is a controlled process, facilitated by chaperones. Proteins that do not fold well elicit several different programmed responses from the cells. A comparison of mutants of growth hormone that result in growth hormone deficiency suggests that cells do not respond in the same way to all growth hormone mutants that cannot fold, because some mutants are...

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PMID: 10668393
DOI: 10.1016/s0083-6729(00)58019-4

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Source receipt: pubmed, retrieved 7 Sept 2026.

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