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Article

Expression of the β (slow)-isoform of MHC in the adult mouse heart causes dominant-negative functional effects

1 Feb 2000

Abstract excerpt

Alpha- and beta-myosin heavy chain (MHC), the two MHC isoforms expressed in the mammalian heart, differ quantitatively in their enzymatic activities. The MHC composition of the heart can change dramatically in response to numerous stimuli, leading to the hypothesis that changes in cardiac function can be caused by myosin isoform shifts. However, this hypothesis has remained unproven because the stimuli used to...

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PMID: 10666070
DOI: 10.1152/ajpheart.2000.278.2.h412

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Source receipt: pubmed, retrieved 7 Sept 2026.

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