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Article

Class I and class II MHC bind self peptide sets that are strikingly different in their evolutionary characteristics.

Immunogenetics - 1 Jan 2000

Yeager M, Carrington M, Hughes A L

Abstract excerpt

Comparison of peptides eluted from human class I and class II major histocompatibility complex (MHC) molecules and the proteins from which they are derived (source proteins) revealed that class I MHC bind peptides derived from proteins that are highly conserved, hydrophilic, and universally expressed, while the peptides themselves are hydrophobic and even more conserved than their source proteins. In contrast,...

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Identifiers

PMID: 10663556
DOI: 10.1007/s002510050002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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