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Article

Regulation of Human 12/15-Lipoxygenase by Stat6-Dependent Transcription

1 Feb 2000

Abstract excerpt

Human 12/15-lipoxygenase is a lipid-peroxidating enzyme implicated in the pathophysiology of atherosclerosis and airway inflammation. Interleukin (IL)-4 specifically induces 12/15-lipoxygenase messenger RNA, protein, and enzymatic activity in primary cultures of human monocytes and airway epithelial cells. The induction of the human 12/15-lipoxygenase by IL-4 suggests that the signal transducer and activator of...

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PMID: 10657944
DOI: 10.1165/ajrcmb.22.2.3786

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