Article
5-methylcytosine at HpaII sites in p53 is not hypermutable after UVC irradiation.
Mutation research - 16 Dec 1999
Monti P, Inga A, Scott G, Aprile A, Campomenosi P, Menichini P, Ottaggio L, Viaggi S, Abbondandolo A, Burns P A, Fronza G
Abstract excerpt
Using a yeast based p53 functional assay we previously demonstrated that the UVC-induced p53 mutation spectrum appears to be indistinguishable from the one observed in Non Melanoma Skin Cancer (NMSC). However, position 742 (codon 248, CpG site) represented the major hot spot in NMSC but was not found mutated in the yeast system. In order to determine whether UVC-induced mutagenic events may be facilitated at...
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