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Article

Intracellular linkers are involved in Mg2+-dependent modulation of the Eag potassium channel.

Channels (Austin, Tex.) - 1 Jan 2000

Liu Xinqiu, Wu Yuying, Zhou Yi

Abstract excerpt

Modulation of activation kinetics by divalent ions is one of the characteristic features of Eag channels. Here, we report that Mg(2+)-dependent deceleration of Eag channel activation is significantly attenuated by a G297E mutation, which exhibits a gain-of-function phenotype in Drosophila by suppressing the effect of shaker mutation on behavior and neuronal excitability. The G297 residue is located in the...

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Identifiers

PMID: 20855938
DOI: 10.4161/chan.4.4.12329
PMCID: PMC3322480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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