Article
Early events in TNFa-p55 receptor interations--experiments with TNF dimers.
Pflugers Archiv : European journal of physiology - 1 Jan 2000
Menart V, Gaberc-Porekar V, Jevsevar S, Pernus M, Meager A, Stalc A
Abstract excerpt
The first essential step in TNF signal transduction is believed to be clustering of the membrane bound receptors around the trimeric TNF molecule. To check if one receptor binding site would be enough to trigger the signal, we tried to prepare several types of TNF dimer. For this purpose, two TNF analogs bearing different cysteine mutations at the inner subunit binding surfaces were designed, expressed in E. coli...
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