Article
The biochemical mechanism of caspase-2 activation.
Cell death and differentiation - 1 Nov 2004
Baliga B C, Read S H, Kumar S
Abstract excerpt
A unified model for initiator caspase activation has previously been proposed based on the biochemical analysis of caspase-8 and -9. Caspase-2 is structurally related to caspase-9, but its mechanism of activation is not known. Using an uncleavable mutant of caspase-2, we show that dimerization (and not processing) is the key event that drives initial procaspase-2 activation. Following dimerization, caspase-2...
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