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Article

A Novel Alzheimer-Associated SNP in Tmp21 Increases Amyloidogenesis.

Molecular neurobiology - 1 Mar 2018

Zhang Xiaojie, Wu Yili, Cai Fang, Liu Shengchun, Bromley-Brits Kelley, Xia Kun, Song Weihong

Abstract excerpt

Recent studies suggest that TMP21 is a selective modulator of γ-secretase and its dysregulation affects APP processing, leading to increased Aβ generation. However, the genetic association between Tmp21 and Alzheimer's disease (AD) remains elusive. In this study, we identified that a novel single-nucleotide polymorphism (SNP) rs12435391 (IVS4-28T>C) in intron 4 of Tmp21 was genetically associated with AD. We...

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Source

Identifiers

PMID: 28233271
DOI: 10.1007/s12035-017-0459-9

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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