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Article

Signalling via ADP-ribosylation factor 6 lies downstream of phosphatidylinositide 3-kinase.

The Biochemical journal - 1 Feb 2000

Venkateswarlu K, Cullen P J

Abstract excerpt

ADP-ribosylation factor (ARF) 6 regulates plasma membrane trafficking and cortical actin formation by cycling between inactive GDP and active GTP-bound conformations. Here we show that agonist stimulation of phosphatidylinositide 3-kinase (PI 3-kinase) activates a pathway that leads to ARF6 activation. We also describe experiments that propose a central role in this pathway for the PI 3-kinase-dependent plasma...

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Identifiers

PMID: 10642533
PMCID: PMC1220809

Genes

ARF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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