Article
A functional polymorphism in the RANTES gene promoter is associated with the development of late-onset asthma.
American journal of respiratory and critical care medicine - 1 Sept 2002
Hizawa Nobuyuki, Yamaguchi Etsuro, Konno Satoshi, Tanino Yoko, Jinushi Eisei, Nishimura Masaharu
Abstract excerpt
The CC chemokine regulated upon activation, normal T-cell expressed and secreted (RANTES) attracts eosinophils, basophils, and T cells during inflammation and immune response, indicating a possible role for this chemokine in asthma. Both the -403A and -28G alleles of the RANTES promoter region exhibit significantly enhanced promoter activity in reporter constructs in vitro. We therefore investigated the genetic...
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