Article
The -403 G-->A promoter polymorphism in the RANTES gene is associated with atopy and asthma.
Genes and immunity - 1 Dec 2000
Fryer A A, Spiteri M A, Bianco A, Hepple M, Jones P W, Strange R C, Makki R, Tavernier G, Smilie F I, Custovic A, Woodcock A A, Ollier W E, Hajeer A H
Abstract excerpt
Asthma is a complex inflammatory condition often associated with bronchial hyperreactivity and atopy. Genetic and environmental factors are implicated and several candidate genes have been implicated. Of these, the chemokine RANTES is responsible for the recruitment of inflammatory cells such as eosinophils and T-lymphocytes. We have recently identified a polymorphism within the RANTES promoter (-403 G-->A) and...
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