PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products.

doi:10.1016/j.chembiol.2008.02.016

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products.

Chemistry & biology - 1 Apr 2008

Jiang Bo, Xu Deming, Allocco John, Parish Craig, Davison John, Veillette Karynn, Sillaots Susan, Hu Wenqi, Rodriguez-Suarez Roberto, Trosok Steve, Zhang Li, Li Yang, Rahkhoodaee Fariba, Ransom Tara, Martel Nick, Wang Hao, Gauvin Daniel, Wiltsie Judyann, Wisniewski Douglas, Salowe Scott, Kahn Jennifer Nielsen, Hsu Ming-Jo, Giacobbe Robert, Abruzzo George, Flattery Amy, Gill Charles, Youngman Phil, Wilson Ken, Bills Gerald, Platas Gonzalo, Pelaez Fernando, Diez Maria Teresa, Kauffman Sarah, Becker Jeff, Harris Guy, Liberator Paul, Roemer Terry

Abstract excerpt

Natural products provide an unparalleled source of chemical scaffolds with diverse biological activities and have profoundly impacted antimicrobial drug discovery. To further explore the full potential of their chemical diversity, we survey natural products for antifungal, target-specific inhibitors by using a chemical-genetic approach adapted to the human fungal pathogen Candida albicans and demonstrate that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspergillus fumigatus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biological Products

Share to Candidiasis

Share to Deoxyadenosines

Share to Drug Evaluation, Preclinical

Share to Drug Resistance, Fungal

Share to Polyadenylation

Share to Polynucleotide Adenylyltransferase

Source

Open in PubMed

Identifiers

PMID: 18420143
DOI: 10.1016/j.chembiol.2008.02.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products.PMID 18420143Read ↗

Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from the Fusarium larvarum complex and other Hypocrealean fungi.Semantic proximity Read ↗

Chemical-Genetic Approaches for Exploring Mode of Action of Antifungal Compounds in the Fungal Pathogen Candida albicans.Semantic proximity Read ↗

Advances in fungal chemical genomics for the discovery of new antifungal agentsSemantic proximity Read ↗

Fungal Genetics, Genomics, and Secondary Metabolites in Pharmaceutical SciencesSemantic proximity Read ↗

Antifungal therapeutic potential of Candida albicans Fun30: screening and validation of novel inhibitors against Candida albicansSemantic proximity Read ↗

Isolation, Structure, and Biological Activities of Fellutamides C and D from an Undescribed Metulocladosporiella (Chaetothyriales) Using the Genome-Wide Candida albicans Fitness TestSemantic proximity Read ↗

Phylogeny-guided discovery of new antifungalsSemantic proximity Read ↗

Systematic Screening of a Glycolysis-targeting Small-molecule Library Identifies Novel Inhibitors of Fungal Morphogenesis in Candida albicansSemantic proximity Read ↗

Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast.Semantic proximity Read ↗

Discovery of novel antifungal (1,3)-beta-D-glucan synthase inhibitors.Semantic proximity Read ↗

An antifungal with a novel mechanism of action discovered via resistance gene-guided genome miningSemantic proximity Read ↗

Amino acid-derived 1,2-benzisothiazolinone derivatives as novel small-molecule antifungal inhibitors: identification of potential genetic targets.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.