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Article

Differential Activity of the Oral Glucan Synthase Inhibitor SCY-078 against Wild-Type and Echinocandin-Resistant Strains of Candida Species.

Antimicrobial agents and chemotherapy - 1 Aug 2017

Pfaller Michael A, Messer Shawn A, Rhomberg Paul R, Borroto-Esoda Katyna, Castanheira Mariana

Abstract excerpt

SCY-078 (formerly MK-3118) is a novel orally active inhibitor of fungal β-(1,3)-glucan synthase (GS). SCY-078 is a derivative of enfumafungin and is structurally distinct from the echinocandin class of antifungal agents. We evaluated the in vitro activity of this compound against wild-type (WT) and echinocandin-resistant isolates containing mutations in the FKS genes of Candida spp. Against 36 Candida spp. FKS...

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Source

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Identifiers

PMID: 28533234
DOI: 10.1128/AAC.00161-17
PMCID: PMC5527608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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