Article
Insertion/deletion polymorphism in the angiotensin-converting enzyme gene affects heart weight.
Circulation - 18 Jan 2000
Nakahara K, Matsushita S, Matsuoka H, Inamatsu T, Nishinaga M, Yonawa M, Aono T, Arai T, Ezaki Y, Orimo H
Abstract excerpt
BACKGROUND: Angiotensin (Ang) II, a major regulatory factor for left ventricular mass, is generated from Ang I by ACE. ACE levels are associated with an insertion/deletion (I/D) polymorphism in the ACE gene. The ACE polymorphism should result in varied Ang II concentrations and hence affect left ventricular mass. We therefore investigated whether ACE genotype is a predictor of heart weight. METHODS AND RESULTS:...
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