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Article

Dissecting the cell-killing mechanism of the topoisomerase II-targeting drug ICRF-193.

The Journal of biological chemistry - 2 Jul 2004

Oestergaard Vibe H, Knudsen Birgitta R, Andersen Anni H

Abstract excerpt

Topoisomerase II is an essential enzyme that is targeted by a number of clinically valuable anticancer drugs. One class referred to as topoisomerase II poisons works by increasing the cellular level of topoisomerase II-mediated DNA breaks, resulting in apoptosis. Another class of topoisomerase II-directed drugs, the bis-dioxopiperazines, stabilizes the conformation of the enzyme where it attains an inactive...

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Identifiers

PMID: 15123716
DOI: 10.1074/jbc.M402119200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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