Article
Functional role of pX open reading frame II of human T-lymphotropic virus type 1 in maintenance of viral loads in vivo.
Journal of virology - 1 Feb 2000
Bartoe J T, Albrecht B, Collins N D, Robek M D, Ratner L, Green P L, Lairmore M D
Abstract excerpt
Human T-lymphotropic virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma and is associated with a variety of immune-mediated disorders. The role of four open reading frames (ORFs), located between env and the 3' long terminal repeat of HTLV-1, in mediating disease is not entirely clear. By differential splicing, ORF II encodes two proteins, p13(II) and p30(II), both of which have not been functionally...
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