Article
Requirement of the human T-cell leukemia virus p12 and p30 products for infectivity of human dendritic cells and macaques but not rabbits.
Blood - 11 Nov 2010
Valeri Valerio W, Hryniewicz Anna, Andresen Vibeke, Jones Kathy, Fenizia Claudio, Bialuk Izabela, Chung Hye Kyung, Fukumoto Risaku, Parks Robyn Washington, Ferrari Maria Grazia, Nicot Christophe, Cecchinato Valentina, Ruscetti Frank, Franchini Genoveffa
Abstract excerpt
The identification of the genes necessary for human T-cell leukemia virus (HTLV-1) persistence in humans may provide targets for therapeutic approaches. We demonstrate that ablation of the HTLV-1 genes encoding p12, p30, or the HBZ protein, does not affect viral infectivity in rabbits and in this species, only the absence of HBZ is associated with a consistent reduction in virus levels. We observed reversion of...
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