Article
The approximately 30-million-year-old ERVPb1 envelope gene is evolutionarily conserved among hominoids and Old World monkeys.
Genomics - 1 Dec 2005
Aagaard Lars, Villesen Palle, Kjeldbjerg Anders Langfelt, Pedersen Finn Skou
Abstract excerpt
Most human endogenous retroviruses (HERVs) are ancient and their genes are rendered nonfunctional by debilitating mutations. One exception is a recently discovered envelope gene located on chromosome 14. This envelope protein was also recently shown to be expressed in various human tissues and to mediate cell-cell fusion ex vivo. In this study, we demonstrate that this locus (designated ERVPb1) is preserved in...
Topics
- Animals
- Base Sequence
- Catarrhini
- Chromosomes, Human, Pair 14
- DNA Primers
- Endogenous Retroviruses
- Evolution, Molecular
- Gene Components
- Humans
- Likelihood Functions
- Models, Genetic
- Molecular Sequence Data
- Phylogeny
- Polymorphism, Single Nucleotide