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Article

Functional properties and sequence variation of HTLV-1 p13.

Retrovirology - 12 May 2020

Omsland Maria, Silic-Benussi Micol, Moles Ramona, Sarkis Sarkis, Purcell Damian F J, Yurick David, Khoury Georges, D'Agostino Donna M, Ciminale Vincenzo, Franchini Genoveffa

Abstract excerpt

Human T cell leukemia virus type-1 (HTLV-1) was the first retrovirus found to cause cancer in humans, but the mechanisms that drive the development of leukemia and other diseases associated with HTLV-1 infection remain to be fully understood. This review describes the functional properties of p13, an 87-amino acid protein coded by HTLV-1 open reading frame II (orf-II). p13 is mainly localized in the inner...

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PMID: 32398094
DOI: 10.1186/s12977-020-00517-1
PMCID: PMC7218495

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