Article
P53 overexpression in colorectal metastases confined to the liver and outcome of liver resection.
Hepato-gastroenterology - 1 Jan 2000
Heisterkamp J, van Bommel J, Hop W C, Tilanus H W, Zondervan P E, IJzermans J N
Abstract excerpt
BACKGROUND/AIMS: The results of hepatic surgery for colorectal metastases are distorted by the high incidence of recurrence, despite an apparently radical resection. Selection of high-risk patients is a mandatory step towards effective application of neo-adjuvant chemotherapy. In this study, expression of the tumor suppresser gene p53 in colorectal liver metastases was correlated with recurrence after resection....
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