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Article

Antagonistic signals between BMP4 and FGF8 define the expression of Pitx1 and Pitx2 in mouse tooth-forming anlage.

Developmental biology - 15 Jan 2000

St Amand T R, Zhang Y, Semina E V, Zhao X, Hu Y, Nguyen L, Murray J C, Chen Y

Abstract excerpt

Members of the Pitx/RIEG family of homeodomain-containing transcription factors have been implicated in vertebrate organogenesis. In this study, we examined the expression and regulation of Pitx1 and Pitx2 during mouse tooth development. Pitx1 expression is detected in early development in a widespread pattern, in both epithelium and mesenchyme, covering the tooth-forming region in the mandible, and is then...

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Share to Bone Morphogenetic Protein 4
Share to Fibroblast Growth Factor 8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeobox Protein PITX2

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Source

Identifiers

PMID: 10625557
DOI: 10.1006/dbio.1999.9547

Genes

BMP4
FGF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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