Article
Characterization of Nfatc1 regulation identifies an enhancer required for gene expression that is specific to pro-valve endocardial cells in the developing heart.
Development (Cambridge, England) - 1 Mar 2005
Zhou Bin, Wu Bingruo, Tompkins Kevin L, Boyer Kathleen L, Grindley Justin C, Baldwin H Scott
Abstract excerpt
Nfatc1 is an endocardial transcription factor required for development of cardiac valves. Herein, we describe identification and characterization of a tissue-specific enhancer in the first intron of murine Nfatc1 that activates a heterogenic promoter and directs gene expression in a subpopulation of endocardial cells of the developing heart: the pro-valve endocardial cells. This enhancer activity begins on...
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