Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The nuclear orphan receptor COUP-TFI is required for differentiation of subplate neurons and guidance of thalamocortical axons.

Neuron - 1 Dec 1999

Zhou C, Qiu Y, Pereira F A, Crair M C, Tsai S Y, Tsai M J

Abstract excerpt

Chicken ovalbumin upstream promotor-transcription factor I (COUP-TFI), an orphan member of the nuclear receptor superfamily, is highly expressed in the developing nervous systems. In the cerebral cortex of Coup-tfl mutants, cortical layer IV was absent due to excessive cell death, a consequence of the failure of thalamocortical projections. Moreover, subplate neurons underwent improper differentiation and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites
Share to Axons
Share to Bromodeoxyuridine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carbocyanines

Share to Fluorescent Dyes

Share to Neural Pathways

Share to Receptors, Glucocorticoid

Share to Thalamus

Source

Identifiers

PMID: 10624948
DOI: 10.1016/s0896-6273(00)81032-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The nuclear orphan receptor COUP-TFI is required for differentiation of subplate neurons and guidance of thalamocortical axons.PMID 10624948Read ↗

Requirement for COUP-TFI and II in the temporal specification of neural stem cells in CNS development.Semantic proximity Read ↗

Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization.Semantic proximity Read ↗

Dynamic expression of COUP-TFI and COUP-TFII during development and functional maturation of the mouse inner ear.Semantic proximity Read ↗

Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex.Semantic proximity Read ↗

The determination of projection neuron identity in the developing cerebral cortex.Semantic proximity Read ↗

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.Semantic proximity Read ↗

Early neocortical regionalization in the absence of thalamic innervation.Semantic proximity Read ↗

Tbr1 and Fezf2 regulate alternate corticofugal neuronal identities during neocortical development.Semantic proximity Read ↗

Chromatin remodeler <i>Arid1a</i> regulates subplate neuron identity and wiring of cortical connectivitySemantic proximity Read ↗

Tcf7l2 plays crucial roles in forebrain development through regulation of thalamic and habenular neuron identity and connectivity.Semantic proximity Read ↗

Tbr1 regulates differentiation of the preplate and layer 6.Semantic proximity Read ↗

A network of genetic repression and derepression specifies projection fates in the developing neocortex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.