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Article

Requirement for COUP-TFI and II in the temporal specification of neural stem cells in CNS development.

Nature neuroscience - 1 Sept 2008

Naka Hayato, Nakamura Shiho, Shimazaki Takuya, Okano Hideyuki

Abstract excerpt

In the developing CNS, subtypes of neurons and glial cells are generated according to a schedule that is defined by cell-intrinsic mechanisms that function at the progenitor-cell level. However, no critical molecular switch for the temporal specification of CNS progenitor cells has been identified. We found that chicken ovalbumin upstream promoter-transcription factor I and II (Coup-tfI and Coup-tfII, also known...

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PMID: 19160499
DOI: 10.1038/nn.2168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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