Article
A specific inhibitor of janus kinase-3 increases survival in a transgenic mouse model of amyotrophic lateral sclerosis.
Biochemical and biophysical research communications - 7 Jan 2000
Trieu V N, Liu R, Liu X P, Uckun F M
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disorder involving the motor neurons of cortex, brain stem, and spinal cord. About 10% of all ALS patients are familial cases (FALS), of which 20% have mutations in the Cu, Zn-superoxide dismutase (SOD1) gene. The murine model for FALS, which overexpresses a FALS variant of the SOD1 gene, exhibits progressive limbic paralysis followed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.