Article

Development of lentiviral vectors targeted to P38MAPK inhibition and Akt activation in motor neurons of a mouse model of familial amyotrophic lateral sclerosis

2010-01-01

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by progressive loss of motor neurons in the cortex, brainstem and spinal cord. This leads to weakness and muscular atrophy that evolves to paralysis and death. Studies on patients and animal models of ALS suggest that the pathology is the consequence of the unbalance between pro-degenerative (p38MAPK) and pro-survival (Akt) pathways i...

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Literature Corpus work: 848f1efb-2179-54fc-bdb8-fe4ac47ce81e
DOI: 10.21954/ou.ro.000100a4

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